Predictors of long-term functional outcomes of juvenile idiopathic arthritis–enthesitis-related arthritis: a single centre experience
Authors' conclusion
PFO was seen in one-half of JIA-ERA in the long-term and was associated with active disease with delay in diagnosis as its sole predictor.
Study context
- Population
- Patients with JIA-ERA with ≥5 years of disease and >16 years of age170 male
- Participants
- 181 patients
- Exposure
- Poor functional outcome (PFO) vs no PFO
- PFOn = 98
- Outcome
- Poor functional outcome (PFO), defined as BASFI > 1.5 or HAQ-DI > 1; predictors
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Predictors of PFO
Delay in diagnosis, PFO vs no PFO (years)
4 vs 2 years
P < 0.001
Arthritis at onset, lower prevalence in PFO (OR, 95% CI)
OR = 0.3; 95% CI: 0.1, 0.8
ERAP1 (rs27044) allele C, higher prevalence in PFO (OR, 95% CI)
OR = 7.2; 95% CI: 1.5, 33.7
Delay in diagnosis, sole predictor of PFO in multivariate analysis (OR, 95% CI)
OR = 1.2; 95% CI: 1.08, 1.4
Observational data: associations, not effects.
Further findings
Disease scores at inclusion, median (IQR)
- ASDAS-ESR
- 2.6 (1.8-3.6)
- BASDAI
- 2.6 (1-5.2)
- HAQ Disability Index (HAQ-DI)
- 0.5 (0-0.5)
- BASFI
- 1.6 (0.3-3.2)
- Delay in diagnosis (years)
- 3 (1-5)
- BASFI and HAQ-DI correlated with ASDAS-ESR, ASDAS-CRP and WHO-QOL-BREF
Persistent disease activity (PDA, BASDAI ≥ 4)
- Patients with PDA
- One-third
- Tarsitis at onset, sole predictor of PDA (OR, 95% CI)
- OR = 2.3; 95% CI: 1.009, 5.4
Original publication
Predictors of long-term functional outcomes of juvenile idiopathic arthritis–enthesitis-related arthritis: a single centre experience. Rheumatology (Oxford). Published 25 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →