Predictors of lack of response to methotrexate in juvenile idiopathic arthritis associated uveitis
Authors' conclusion
Younger age at JIA onset, polyarticular course and a history of systemic steroids' use are predictors of a worse response to MTX in JIA-U.
Study context
- Population
- JIA-associated uveitis (JIA-U) patients treated with MTX; 82.8% female; mean age at uveitis onset 5.7 yearsmean follow up 9.2 years
- Participants
- 99 participants
- Exposure
- MTX non-responders vs MTX responders
- MTX non-respondersn = 65
- Outcome
- Lack of response to MTX (requirement of a bDMARD)
Methodological detailsunivariate Cox regression, Kaplan-Meier curves, multivariable logistic model
- Univariate Cox regression
- Kaplan-Meier curves
- Multivariable logistic model
Main finding
As reported in the abstract
Requirement of ≥1 bDMARD to control uveitis
MTX non-responders
65.7%
65
Observational data: associations, not effects.
Further findings
Characteristics of children requiring biological disease-modifying antirheumatic drug (bDMARD)
- Lower age at JIA and uveitis onset, more frequent polyarticular course, more bilateral uveitis at onset, higher prevalence of systemic steroid use
Ocular damage · last visit
- Similar frequency at onset; higher percentage at last visit in MTX non-responders
Original publication
Predictors of lack of response to methotrexate in juvenile idiopathic arthritis associated uveitis. Rheumatology (Oxford). Published 8 February 2024. doi:10.
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