Clinical characteristics of adolescent-onset gout in Chinese: A hospital-based cross-sectional study
Authors' conclusion
Adolescent-onset gout patients had clinically distinctive features with higher SU levels, BMI, positive gout family history, underexcretion type and recurrent flares.
Study context
- Population
- Chinese patients with gout
- Participants
- 9,003 patients
- Exposure
- Adolescent-onset vs early-onset vs late-onset gout
- Outcome
- Clinical features by gout onset age
Methodological detailshospital-based, multivariable regression analysis
- Hospital-based
- Multivariable regression analysis
Main finding
As reported in the abstract
- Serum urate (SU) levels: AG 9.5 (2.2) mg/dL, EG 8.6 (2.1) mg/dL, LG 7.73 (2.0) mg/dL
- P < 0.001
- Positive family history of gout: AG 41.8 %, EG 29.6 %, LG 24.6 %
- P < 0.001
- Underexcretion type: AG 62.4 %, EG 62.5 %, LG 58.8 %
- P = 0.04
- Recurrent flares: AG 78.1 %, EG 70.3 %, LG 68.9 %
- P = 0.01
Observational data: associations, not effects.
Further findings
Factors associated with recurrent flares in AG
| OR (95 % CI) | ||
|---|---|---|
| ULT initiated | 6.58 (1.35–32.00) | |
| Hypercholesterolemia | 4.16 (1.28–13.53) | |
| 0.050.21520Odds ratio (log scale) |
Factors associated with underexcretion type in AG
| OR (95 % CI) | ||
|---|---|---|
| Hypertriglyceridemia | 0.35 (0.17–0.71) | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | Beta (95 % CI) |
|---|---|
| Factors associated with increasing SU levels in AG | −0.24 (−0.04 to −0.01) |
Original publication
Clinical characteristics of adolescent-onset gout in Chinese: A hospital-based cross-sectional study. Semin Arthritis Rheum. Published 5 February 2024. doi:10.
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