Predictors of fibrogenesis in children with juvenile idiopathic arthritis (JIA): a single-center pilot study
Authors' conclusion
Children with JIA had higher bFGF and VEGF levels when JIA onset occurred after 15 years of age, depending on disease activity.
Study context
- Population
- Children with JIA (polyarthritis 64.29%, oligoarthritis 35.71%; mean age 13.3 years; 64.29% girls)
- Participants
- 70 children
- Outcome
- Early markers of fibrosis formation: bFGF and VEGF levels (ELISA)
Methodological detailssingle-centre, pilot study, 4-year prospective
- Single-centre
- Pilot study
- 4-year prospective
Main finding
As reported in the abstract
Basic fibroblast growth factor (bFGF), mean (min–max 4171.56–18,011.25 pg/ml)
7478.21 pg/ml
Vascular endothelial growth factor (VEGF), mean (min–max 23.68–2158.91 pg/ml)
342.47 pg/ml
Observational data: associations, not effects.
Original publication
Predictors of fibrogenesis in children with JIA: a single-center pilot study. Pediatr Rheumatol Online J. Published 2 January 2024. doi:10.
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