Potential role of type I interferon/IP-10 axis in the pathogenesis of anti-MDA5 antibody-positive dermatomyositis
Authors' conclusion
IP-10 is a potentially useful disease activity marker of DM with anti-MDA5 antibodies, correlating more with IFN-α2 then IFN-γ.
Study context
- Population
- Patients with collagen vascular diseases; serum level of 28 cytokines quantified at hospital admission3 anti-MDA5+ dermatomyositis (DM) followed up
- Comparison
- DM with anti-MDA5 antibodies vs DM without the antibody
Methodological detailsbead-based multiplex immunoassays, immunohistochemistry, in vitro monocyte stimulation
- Bead-based multiplex immunoassays
- Immunohistochemistry
- In vitro monocyte stimulation
Main finding
As reported in the abstract
- Serum IP-10 significantly higher in DM with anti-MDA5 antibodies than in those without, decreasing drastically upon treatment
- Time course of IP-10 paralleled interferon (IFN)-α2, not IFN-γ
- Most IP-10-positive cells in skin were macrophages
- Monocytes stimulated with type I IFN in vitro produced IP-10 in a dose-dependent manner
Original publication
Potential role of type I interferon/IP-10 axis in the pathogenesis of anti-MDA5 antibody-positive dermatomyositis. Clin Exp Rheumatol. Published 6 September 2022. doi:10.
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