Post-hoc analysis of two gout remission definitions in a two-year randomized controlled trial of nurse-led versus usual gout care
Authors' conclusion
Both definitions discriminated between the intervention groups and showed high construct validity. The simplified definition identified more people as being in gout remission at Year 1 and Year 2.
Study context
- Population
- Community-derived people with goutrandomised 1:1
- Participants
- 517 people
- Comparison
- Nurse-led gout care vs GP usual care; 2016 preliminary vs simplified gout remission definition
- Primary endpoint
- Gout remission by the 2016 preliminary definition and by a simplified definition without patient reported outcomes
- Follow-up
- Year 2
Methodological details2-year, parallel arm, non-blinded
- 2-year
- Parallel arm
- Non-blinded
Primary result
As reported in the abstract
Remission by 2016 preliminary and simplified definitions, nurse-led vs usual care
Each group vs usual careEstimate (95 % CI)
Nurse-led care
OR for achieving remission (2016 preliminary definition) 7.92(4.86–12.92)
Nurse-led care
OR for achieving remission (simplified definition) 11.88(7.49–18.84)
Further findings
Remission fulfilled, all participants, 2016 preliminary definition · Year 1 and Year 2
- Year 1
- 9.9 %
- Year 2
- 28.4 %
- Year 1 vs Year 2
- P < 0.001
Remission fulfilled, all participants, simplified definition · Year 1 and Year 2
- Year 1
- 17.6 %
- Year 2
- 42.7 %
- Year 1 vs Year 2
- P < 0.001
Gout Impact Scale (GIS) scores, remission vs no remission
- People in remission by either definition had better gout outcomes on the GIS, including greater control over their gout
Original publication
Post-hoc analysis of two gout remission definitions in a two-year randomized controlled trial of nurse-led versus usual gout care. Semin Arthritis Rheum. Published 18 September 2024. doi:10.
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