Plasma levels of multiple cardiovascular- and inflammation-related proteins analysed for associations with disease activity and anti-cyclic citrullinated peptide status in active early rheumatoid arthritis
Authors' conclusion
In active and early RA, the findings regarding CHIT1, SHPS-1 TIMP-4, IL2-RA, E-selectin, and CCL16 differed between the two anti-CCP groups. In addition, we identified two patient clusters that were independent of the anti-CCP status.
Study context
- Population
- Early, treatment-naive, highly inflamed rheumatoid arthritis (RA) patients from the OPERA trial
- Participants
- 180 participants
- Exposure
- Anti-CCP-negative vs anti-CCP-positive early RA
- Anti-CCP-negativen = 63
- Anti-CCP-positiven = 117reference
- Outcome
- Plasma levels of 92 cardiovascular- and inflammation-related proteins (Olink CVD-III panel) and their correlation with RA disease activity, by anti-CCP status
Methodological detailshierarchical cluster analysis
- Hierarchical cluster analysis
Main finding
As reported in the abstract
CIRP plasma levels by anti-CCP status
- CHIT1 and SHPS-1 increased and TIMP-4 decreased in anti-CCP-negative vs anti-CCP-positive
- Strongest associations with disease activity: IL2-RA and E-selectin in anti-CCP-negative; CCL16 in anti-CCP-positive
- None of the differences passed the Hochberg sequential multiplicity test; Cardiovascular- and inflammation-related proteins (CIRPs) were interacting, so the procedure's prerequisites were not fulfilled
Observational data: associations, not effects.
Further findings
CIRP level-based cluster analysis
- Two patient clusters identified in both anti-CCP groups; demographic and clinical characteristics similar in the two clusters for each anti-CCP group
Original publication
Plasma levels of multiple cardiovascular- and inflammation-related proteins analysed for associations with disease activity and anti-cyclic citrullinated peptide status in active early rheumatoid arthritis. Clin Exp Rheumatol. Published 1 October 2022. doi:10.
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