Peripheral expansion of myeloid-derived suppressor cells is related to disease activity and damage accrual in inflammatory myopathies
Authors' conclusion
MDSCs expressing arginase-1 and PD-L1 are expanded in IIM and correlate with disease activity, damage accrual and serum cytokines.
Study context
- Population
- Adult patients with IIM (mostly DM) and healthy donors, Mexico CityDM n = 30 (81.0%)
- Participants
- 37 vs 10
- Exposure
- IIM patients vs healthy donors; active vs inactive disease
- IIMn = 37
- Healthy donorsn = 10reference
- Outcome
- Proportion of myeloid-derived suppressor cells (MDSCs), their expression of arginase-1 and PD-L1, and relationship with clinical phenotype
Methodological detailsflow cytometry, multiplex cytokine assay
- Flow cytometry
- Multiplex cytokine assay
Main finding
As reported in the abstract
MDSCs in IIM vs healthy donors
- IIM patients had a peripheral expansion of PMN-MDSCs and M-MDSCs with an enhanced expression of arginase-1 and PD-L1
Observational data: associations, not effects.
Further findings
Absolute number of PD-L1+ M-MDSCs, active vs inactive disease
P = 0.046
PD-L1 expression on M-MDSCs, active vs inactive disease
P = 0.038
Median
| Outcome | Active disease | Inactive disease | P value |
|---|---|---|---|
| M-MDSCs (%), active vs inactive disease | 1.75% (IQR 0.31–5.50) | 10.71 (IQR 3.16–15.58) | P = 0.011 |
Correlations of PD-L1 expression in PMN-MDSCs (Spearman)
- Pulmonary disease activity VAS
- r = 0.34, P = 0.040
- Pulmonary damage VAS
- r = 0.36, P = 0.031
- Serum IL-5
- r = 0.55, P = 0.003
- Serum IL-6
- r = 0.46, P = 0.003
- Serum IL-8
- r = 0.53, P = 0.018
- Serum IL-10
- r = 0.48, P = 0.005
- Serum GM-CSF
- r = 0.48, P = 0.012
Correlations of M-MDSCs (Spearman)
- Skeletal Myositis Intention to Treat Index (negative)
- r = −0.34, P = 0.038
- IL-6 (positive)
- r = 0.40, P = 0.045
Original publication
Peripheral expansion of myeloid-derived suppressor cells is related to disease activity and damage accrual in inflammatory myopathies. Rheumatology (Oxford). Published 29 June 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →