Idiopathic inflammatory myopathies lack neutralising autoantibodies to type- I, II and III interferons
Authors' conclusion
We did not detect neutralising autoantibodies against IFN-α and autoantibodies against other types of IFNs in a Swedish cohort of IIM patients.
Study context
- Population
- Swedish patients with IIM (ASyS and DM) and matched blood donors
- Exposure
- ASyS and DM patients vs matched blood donors from general population
- Anti-synthetase syndromen = 51
- Dermatomyositisn = 48
- Blood donorsn = 100reference
- Outcome
- Autoantibodies against type-I, II and III interferons (IFNs) and their neutralising activity
Methodological detailsobservational, matched blood donors, planar and suspension-based multiplex assays, in vitro IFN-α/β responsive cell reporter assay
- Observational
- Matched blood donors
- Planar and suspension-based multiplex assays
- In vitro IFN-α/β responsive cell reporter assay
Main finding
As reported in the abstract
- No evidence of anti-IFN (type-I, II or III) autoantibodies in any IIM subgroup or blood donors
- No plasma sample except the APS-1 neutralised physiological concentration IFN-α2
Observational data: associations, not effects.
Further findings
- Repertoire of autoantibodies in IIM patients against a number of common myositis-specific and myositis-associated antigens
Original publication
Idiopathic inflammatory myopathies lack neutralising autoantibodies to type- I, II and III interferons. RMD Open. Published 25 September 2025. doi:10.
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