Clinical characteristics of patients with antisynthetase syndrome and dermatomyositis-type skin involvement: Insights from the Myo-Spain registry
Authors' conclusion
ASyS-DM-skin patients displayed a distinct clinical phenotype, characterized by DM-type cutaneous involvement while retaining ASyS features, particularly interstitial lung disease, Raynaud's phenomenon, and mechanic's hands.
Study context
- Population
- Baseline data from the Spanish registry of patients with IIM (Myo-Spain): patients with anti-synthetase syndrome (ASyS) and dermatomyositis (DM)194 ASyS, 116 DM
- Exposure
- ASyS with DM-type skin lesions vs ASyS without DM-type skin lesions and vs DM
- ASyS-DM-skinn = 61
- DMn = 116
- Outcome
- Factors associated with DM-type skin lesions among ASyS patients (multivariable)
Methodological detailsregistry-based (Myo-Spain), multivariable logistic regression
- Registry-based (Myo-Spain)
- Multivariable logistic regression
Main finding
As reported in the abstract
Periungual capillary alterations: OR
2.49
95% CI 1.10–5.65
Age at diagnosis: OR
0.97
95% CI 0.94–0.99
Arthralgia: OR
0.39
95% CI 0.15–1.00
Observational data: associations, not effects.
Further findings
Factors associated with ASyS diagnosis among patients with DM-type skin lesions (multivariable)
- Raynaud's phenomenon: OR
- 6.84 (95% CI 1.04-44.81)
- Mechanic's hands: OR
- 12.60 (95% CI 1.55-102.7)
- ILD: OR
- 27.83 (95% CI 4.55-170.5)
- Heliotrope rash or Gottron sign/papules: OR
- 0.10 (95% CI 0.01-0.73)
- Muscle weakness at diagnosis: OR
- 0.11 (95% CI 0.01-0.83)
Malignancy
- Less frequent in ASyS-DM-skin than in DM
Original publication
Clinical characteristics of patients with antisynthetase syndrome and dermatomyositis-type skin involvement: Insights from the Myo-Spain registry. Semin Arthritis Rheum. Published 29 July 2026. doi:10.
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