Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry
Authors' conclusion
Recent diagnosis is associated with greater disease activity, as assessed based on these activity outcomes.
Study context
- Population
- Patients with different diagnostic subgroups of idiopathic inflammatory myopathy (IIM) in the Spanish Myo-Spain registry215 ASA-positive
- Participants
- 554 patients
- Exposure
- Incident vs prevalent IIM cases; ASA-positive patients
- Incidentn = 136
- Prevalentn = 418reference
- Outcome
- Main disease activity outcomes: MYOACT, MMT-8, PhGA and extramuscular activity
Methodological detailsmulticentre, registry-based (Myo-Spain), multivariate generalized linear model, simple linear regression
- Multicentre
- Registry-based (Myo-Spain)
- Multivariate generalized linear model
- Simple linear regression
Main finding
As reported in the abstract
Main disease activity outcomes
- All measures of disease activity higher in incident cases, except MYOACT muscular and creatine phosphokinase (no differences in ASA-positive patients)
- p < 0.05
- Prevalent cases negatively associated with main activity outcomes, except MMT-8 (positive association)
- p < 0.05
- ASA positivity positively associated with MYOACT and negatively with MMT-8; no association with physician global activity (PhGA) and extramuscular activity
- p < 0.05
Observational data: associations, not effects.
Further findings
Measures of damage
- No differences between incident and prevalent cases
SF-12 physical component
- Higher in prevalent cases
- P < 0.05
Original publication
Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry. Arthritis Res Ther. Published 8 January 2025. doi:10.
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