PD1 + TIGIT + CD4 + T cells predict response to anti-TNF in rheumatoid arthritis and spondyloarthritis
Authors' conclusion
CD8+PD-1+TIGIT+ T-cell expression is elevated in SjD and RA compared with HV and AS. CD4+PD-1+TIGIT+ levels are higher in future anti-TNF responders compared with non-responders and rise after treatment in patients with RA and AS.
Study context
- Population
- Biologics-naïve patients with rheumatoid arthritis (RA) and spondyloarthritis followed prospectively for anti-TNF response; Sjögren's disease (SjD) patients and healthy volunteers at baseline
- Participants
- 67 patients
- Exposure
- Baseline CD4+PD-1+TIGIT+ levels in future anti-TNF responders vs non-responders
- Outcome
- Anti-TNF response
- Follow-up
- 12 months
Methodological detailsflow cytometry, biomarker study
- Flow cytometry
- Biomarker study
Main finding
As reported in the abstract
Baseline CD4+PD-1+TIGIT+ levels
P = 0.003
Observational data: associations, not effects.
Further findings
Median
| Outcome | RA | SjD | HV | AS |
|---|---|---|---|---|
| Median CD8+PD-1+TIGIT+ levels by disease · baseline | 24% | 23.2% | 18.8% | 16.2% |
Median CD8+PD-1+TIGIT+ levels by disease · baseline
- Higher in RA and SjD than in healthy volunteers (HV) and and spondyloarthritis (AS)
Correlations of CD4+PD-1+TIGIT+ with circulating markers in SjD
- Immunoglobulin G, r (p<0.001)
- 0.698
- Interferon gamma, r (p=0.017)
- 0.635
- IP-10, r (p=0.005)
- 0.612
CD4+PD-1+TIGIT+ and CD8+PD-1+TIGIT+ cells after anti-TNF in RA and AS · 3 months
- Both increased after 3 months of anti-TNF treatment
Original publication
PD1 + TIGIT + CD4 + T cells predict response to anti-TNF in rheumatoid arthritis and spondyloarthritis. RMD Open. Published 20 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →