Lupus & antiphospholipid syndrome
Patients with systemic lupus erythematosus who are underweight have distinct disease characteristics
Main finding · High disease activity (SLEDAI-2K ≥10)Result — go to the resultAdjusted odds ratio 0.38 95% CI 0.16–0.92Authors' conclusion
Patients with SLE who were underweight showed less renal involvement and lower SLEDAI-2K scores compared with those who were not underweight. Moreover, those with SLE who were underweight had a 60% lower risk of exhibiting high disease activity.
Study context
- Population
- Patients newly diagnosed with systemic lupus erythematosus (SLE)
- Participants
- 218 patients
- Exposure
- Underweight vs not underweight
- Underweightn = 35
- Not underweightn = 183reference
- Outcome
- High disease activity (SLEDAI-2K ≥10) at diagnosis
- Follow-up
- At diagnosis
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Main finding
High disease activity (SLEDAI-2K ≥10)
Adjusted odds ratio
0.38
95% CI 0.16–0.92
P = 0.031
By group
Underweightvs Not underweight
aOR 0.38 (95% CI 0.16–0.92); P = 0.031
As reported in the abstract
Observational data: associations, not effects.
Further findings
Renal involvement · at diagnosis
P = 0.040
CRP · at diagnosis
P = 0.028
| Outcome | Underweight | Not underweight | P value |
|---|---|---|---|
| SLEDAI-2K score · at diagnosis | 6.7 ± 4.6 | 9.1 ± 5.7 | P = 0.009 |
Original publication
Patients with systemic lupus erythematosus who are underweight have distinct disease characteristics. Lupus. Published 5 December 2023. doi:10.
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