Lupus & antiphospholipid syndrome
Patient-reported outcome measures in patients with systemic lupus erythematosus with or without concurrent fibromyalgia
Authors' conclusion
SLE patients with non-FM chronic pain have similar symptoms to FM compared with SLE patients without chronic pain; however, symptoms are not as severe as those meeting FM criteria.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) in a convenience cohort, categorised by 2016 American College of Rheumatology (ACR) fibromyalgia (FM) Survey
- Participants
- 181 patients
- Exposure
- SLE with concurrent FM chronic pain vs non-FM chronic pain vs no chronic pain
- FM painn = 31
- Non-FM chronic painn = 23
- No chronic painn = 127reference
- Outcome
- PROMIS measures (e.g., depression, fatigue) by pain group
Methodological detailsconvenience cohort
- Convenience cohort
Main finding
As reported in the abstract
PROMIS measures by pain group
- Median Patient-Reported Outcomes Measurement Information System (PROMIS) symptom scores (fatigue, sleep disturbance, pain intensity and interference, depression) highest and cognitive function lowest in the FM group, despite 13% being in remission
- FM pain vs Non-FM chronic pain: P < 0.02
Observational data: associations, not effects.
Further findings
- No significant differences in SLE Disease Activity Index (SLEDAI) score
Original publication
Patient-reported outcome measures in patients with systemic lupus erythematosus with or without concurrent fibromyalgia. Lupus. Published 16 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →