Pain sensitisation and joint inflammation in patients with active rheumatoid arthritis
Authors' conclusion
The unexpected group -FM-PD group may have peripheral nociplastic pain, not commonly recognised in rheumatology. Only 46% of patients demonstrated PDUS+ inflammation. However clinical examination and PROMs did not reliably differentiate groups
Study context
- Population
- Sequential rheumatoid arthritis (RA) patients with at least moderate DAS28-ESR disease activity
- Participants
- 158 patients
- Exposure
- Fibromyalgia (FM) criteria and PDUS+ joint inflammation categories
- -FM-PDn = 43
- -FM+PDn = 43
- +FM-PDn = 42
- +FM+PDn = 30
- Outcome
- FM criteria (ACR 2010) and PDUS+ joint inflammation
Methodological detailssequential patients, logistic regression, regularised (lasso) logistic regression
- Sequential patients
- Logistic regression
- Regularised (lasso) logistic regression
Main finding
As reported in the abstract
- Met FM criteria
- 72 (46%)
Observational data: associations, not effects.
Original publication
Pain sensitisation and joint inflammation in patients with active rheumatoid arthritis. RMD Open. Published 19 March 2024. doi:10.
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