Outcomes following SARS-CoV-2 infection in individuals with and without inflammatory rheumatic diseases: a Danish nationwide cohort study
Main finding · Time to first positive SARS-CoV-2 testResult — go to the resultIncidence rate ratio 1.06 95% CI 1.05–1.07Authors' conclusion
Patients with IRD have a risk of SARS-CoV-2, which nearly corresponds to the general population but had a substantial increased risk of hospitalisation with COVID-19, severe COVID-19, requiring assisted ventilation and COVID-19 leading to death, especially in patients with comorbidities.
Study context
- Population
- Danish patients with inflammatory rheumatic diseases (IRD) and matched population controls, March 2020 to January 2023matched cohort
- Participants
- 66,840 vs 668,400
- Exposure
- Patients with IRD vs matched population controls
- IRDn = 66,840
- Population controlsn = 668,400reference
- Outcome
- Contracting SARS-CoV-2 (time to first positive test) and prognosis: hospitalisation, assisted ventilation and death
Methodological detailsmatched population controls, Cox regression
- Matched population controls
- Cox regression
Main finding
Time to first positive SARS-CoV-2 test
Incidence rate ratio
1.06
95% CI 1.05–1.07
IRDvs Population controls
IRR 1.06 (95% CI 1.05–1.07)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | IRR (95% CI) | |
|---|---|---|
| Time to second positive SARS-CoV-2 test | 1.21 (1.15–1.27) | |
| Hospital contact with COVID-19 | 2.11 (1.99–2.23) | |
| Severe COVID-19 | 2.18 (1.94–2.45) | |
| 0.512Incidence rate ratio (log scale) |
Third SARS-CoV-2 vaccination
- Associated with reduced need for hospitalisation with COVID-19 and reduced risk of death
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Outcomes following SARS-CoV-2 infection in individuals with and without inflammatory rheumatic diseases: a Danish nationwide cohort study. Ann Rheum Dis. Published 6 July 2023. doi:10.
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