Prevalence of latent tuberculosis infection (LTBI) in patients with autoimmune diseases and accuracy of IFN-gamma release assay (IGRA) in predicting tuberculosis (TB) relapse
Authors' conclusion
LTBI screening is beneficial in AIRDs patients prior to the prescription of biologics or tsDMARDs. IGRA is ideal for identifying patients with increased likelihood of developing TB upon receiving biologics or tsDMARDs with reasonable accuracy.
Study context
- Population
- Indian patients with autoimmune rheumatic diseases screened with IGRA before biologics or tsDMARDs (mean age 42.93 ± 14.01 years; M:F 1:2.08; RA most common, 43.16%)
- Participants
- 943 patients
- Exposure
- LTBI positive vs LTBI negative
- LTBI positiven = 125
- LTBI negativen = 816reference
- Outcome
- LTBI positivity and accuracy of IGRA in predicting absence of TB reactivation
Methodological detailsretrospective, chart-based
- Retrospective
- Chart-based
Main finding
As reported in the abstract
LTBI positive
125
events
LTBI negative
816
events
- Accuracy of IGRA in predicting absence of TB reactivation
- 99.6%
- Error rate
- 0.46
Observational data: associations, not effects.
Further findings
Number of DMARDs or immune suppressants received
- Single
- 54.35%
- Double
- 33.33%
- Triple or more
- 7.69%
Original publication
Prevalence of LTBI in patients with autoimmune diseases and accuracy of IGRA in predicting TB relapse. Rheumatology (Oxford). Published 22 June 2023. doi:10.
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