Lupus & antiphospholipid syndrome
Outcome clusters and their stability over 1 year in patients with SLE: self-reported and performance-based cognitive function, disease activity, mood and health-related quality of life
Authors' conclusion
Three distinct clusters of symptom intensity were documented in patients with SLE in association with cognitive function. There was a lower tendency for patients in the mild and severe clusters to move but not moderate cluster over the course of a year.
Study context
- Population
- Consecutive consenting patients with SLE followed at a single centre
- Participants
- 142 participants
- Exposure
- Cluster 1 vs Cluster 2 vs Cluster 3
- Outcome
- Clustering of self-reported fatigue, anxiety, depression, cognitive difficulties, health-related quality of life, disease activity (SLEDAI-2K) and neuropsychological battery by symptom intensity, and change at 1-year follow-up
- Follow-up
- 1 year
Methodological detailssingle-centre, consecutive consenting patients, Ward's method clustering, principal component analysis, kappa statistic for 1-year stability
- Single-centre
- Consecutive consenting patients
- Ward's method clustering
- Principal component analysis
- Kappa statistic for 1-year stability
Main finding
As reported in the abstract
1-year follow-up
| Group | Value | Moved to severe cluster | Moved to moderate cluster | Moved to mild cluster |
|---|---|---|---|---|
| Cluster 1 | 77% | 19% | ||
| Cluster 2 | 3% | |||
| Cluster 3 | 51% | 40% | 9% |
Value
Cluster 177%
Cluster 23%
Cluster 351%
Moved to severe cluster
Cluster 119%
Cluster 2— not stated in the abstract
Cluster 3— not stated in the abstract
Moved to moderate cluster
Cluster 1— not stated in the abstract
Cluster 2— not stated in the abstract
Cluster 340%
Moved to mild cluster
Cluster 1— not stated in the abstract
Cluster 2— not stated in the abstract
Cluster 39%
- Patients remaining in baseline cluster at 1 year
- 49%
Observational data: associations, not effects.
Original publication
Outcome clusters and their stability over 1 year in patients with SLE: self-reported and performance-based cognitive function, disease activity, mood and health-related quality of life. Lupus Sci Med. Published 11 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →