Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking
Main finding · ACPA-positive RAResult — go to the resultOdds ratio 1.25 95% CI 1.12–1.38Authors' conclusion
Occupational inhalable agents could act as important environmental triggers in RA development and interact with smoking and RA-risk genes leading to excessive risk for ACPA-positive RA.
Study context
- Population
- Swedish Epidemiological Investigation of rheumatoid arthritis (RA): incident RA cases and matched controls32 inhalable agents assessed
- Participants
- 4,033 vs 6,485
- Comparison
- Exposure to any occupational inhalable agents vs no exposure
- RA casesn = 4,033
- Controlsn = 6,485reference
- Outcome
- ACPA-positive RA associated with exposure to any occupational inhalable agents
Methodological detailsmatched controls, unconditional logistic regression, job-exposure matrix
- Matched controls
- Unconditional logistic regression
- Job-exposure matrix
Main finding
ACPA-positive RA
Odds ratio
1.25
95% CI 1.12–1.38
Exposure to any occupational inhalable agentsvs no exposure
OR 1.25 (95% CI 1.12–1.38)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| ACPA-positive RA, joint exposure to occupational inhalable agents, smoking and high GRSTriple-exposedvs Not exposed to any | 18.22 (11.77–28.19) | |
| 0.050.21520Odds ratio (log scale) |
Interaction in anticitrullinated protein antibodies (ACPA)-positive RA
- Significant interactions between occupational inhalable agents and smoking/genetic factors (high Genetic Risk Score (GRS) or HLA-SE)
- Attributable proportion due to interaction
Original publication
Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking. Ann Rheum Dis. Published 6 December 2022. doi:10.
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