Exposure to air pollutants and rheumatoid arthritis biomarkers: A scoping review
Authors' conclusion
Based on mixed results, there was no consistent link between any single pollutant and RA-related biomarker outcomes.
Study context
- Population
- Epidemiological studies that measured or estimated air pollution and at least one rheumatoid arthritis (RA) biomarker13 studies
- Comparison
- Exposure to environmental and occupational air pollutants and RA biomarkers (rheumatoid factor (RF), anti-citrullinated peptide antibody (ACPA))
- Outcome
- Association between air pollutant exposure and RA-related biomarkers RF and ACPA
Methodological detailsPubMed and Web of Science search, epidemiological studies
- PubMed and Web of Science search
- Epidemiological studies
Main finding
As reported in the abstract
- Associations of industrial sulfur dioxide and PM2.5 with ACPA observed most frequently, incl. residential proximity to pollution sources and ACPA positivity
- Consistency of associations with other pollutants either not observed or limited to single studies
- 3 studies evaluated effect modification by SE alleles: pollutant associations stronger in SE allele-positive participants
Original publication
Exposure to air pollutants and rheumatoid arthritis biomarkers: A scoping review. Semin Arthritis Rheum. Published 5 January 2024. doi:10.
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