Lupus & antiphospholipid syndrome
Obesity is an independent poor prognostic factor in lupus nephritis
Authors' conclusion
A BMI ≥30 kg/m2 is an independent poor prognostic factor for the progression of CKD in LN.
Study context
- Population
- Biopsy-proven class III, IV or V incident lupus nephritis (LN) with quarterly data over a long follow-up (median 140 months)
- Participants
- 132 participants
- Exposure
- Obese vs non-obese patients with LN
- Outcome
- CKD G3 (eGFR <60 mL/min/1.73 m²)
Methodological detailsmultivariate analysis
- Multivariate analysis
Main finding
As reported in the abstract
Progression of CKD (CKD G3; eGFR <60 mL/min/1.73 m²) · long-term (median follow-up 140 months)
- Obesity, long-term risk for progression of CKD: HR
- 2.72 (1.11-6.64), p = .028 (95% CI)
- Obesity an independent risk factor for CKD G3 in multivariate analysis
- p = .029
Observational data: associations, not effects.
Further findings
Renal flare
- Time to renal flare statistically shorter in obese patients
Baseline characteristics
- Baseline characteristics did not differ between obese and non-obese patients
Original publication
Obesity is an independent poor prognostic factor in lupus nephritis. Lupus. Published 17 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →