Notable lacking of bone mineral density measurement in cushing syndrome: a nationwide study based on the US insurance claim database
Authors' conclusion
Despite guideline recommendations, only 6.40% of patients with Cushing's syndrome underwent BMD screening. Among those screened, 12.56% were diagnosed with osteoporosis..
Study context
- Population
- Patients diagnosed with Cushing's syndrome, PearlDiver Patient Records Database (2010–2020), excluding prior osteoporosis diagnoses
- Participants
- 53,101 patients
- Outcome
- BMD testing within two years of diagnosis
- Follow-up
- Two years of diagnosis
Methodological detailsnationwide, US insurance claims database (PearlDiver, 2010-2020), logistic regression
- Nationwide
- US insurance claims database (PearlDiver, 2010-2020)
- Logistic regression
Main finding
As reported in the abstract
two years
Underwent bone mineral density (BMD) testing
6.40%
Observational data: associations, not effects.
Further findings
Factors associated with BMD testing (logistic regression)
| OR | P value | |
|---|---|---|
| Male gender | 0.31 | P < 0.001 |
| Older age | 0.96 | P < 0.001 |
| Higher ECI scores | 0.89 | P < 0.001 |
| Obesity | 1.51 | P < 0.001 |
| CKD | 1.38 | P < 0.001 |
| Outcome | Values | P value |
|---|---|---|
| BMD testing by sexFemales vs Males | Females 7.85% · Males 2.58% | P < 0.001 |
| Age, tested vs not tested | Tested mean 62.79 years · Not tested mean 65.21 years | P < 0.001 |
Testing rate by region and insurance
- Midwest region, highest testing rate
- 7.1%
- Commercial insurance, highest testing frequency
- 7.5%
Osteoporosis diagnosis among those tested
- Diagnosed with osteoporosis
- 12.56%
- Older age and tobacco use significantly increased odds of diagnosis
Original publication
Notable lacking of bone mineral density measurement in cushing syndrome: a nationwide study based on the US insurance claim database. Osteoporos Int. Published 18 March 2025. doi:10.
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