Impact of Mediterranean diet on mortality in vertebral compression fracture patients
Authors' conclusion
We found aMED have a moderating effect on the association between VCF patients and mortality.
Study context
- Population
- Patients aged ≥ 40 years with vertebral compression fractures (VCF) measurement (bone mineral density (BMD) DXA), National Health and Nutrition Examination Survey (NHANES) 2013–2014218 (7.99%) deaths
- Participants
- 2,730 patients
- Exposure
- aMED score < 6 vs aMED score ≥ 6, and VCF vs no VCF
- Outcome
- All-cause and CVD-cause mortality
- Follow-up
- Until 12 December 2019
Methodological detailsNHANES 2013-2014, weighted multivariable Cox proportional hazards models, subgroup analyses
- NHANES 2013-2014
- Weighted multivariable Cox proportional hazards models
- Subgroup analyses
Main finding
As reported in the abstract
VCF, aMED < 6 vs No VCF, aMED ≥ 6Hazard ratio (95% CI)P value
All-cause mortality
2.27(1.25–4.13)
P = 0.025CVD-cause mortality
4.25(1.64–11.06)
P = 0.013Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality, aMED < 6 vs aMED ≥ 6aMED < 6vs aMED ≥ 6All-cause mortality | 2.26 (1.22–4.17) | P = 0.002 | |
| Mortality, aMED < 6 vs aMED ≥ 6aMED < 6vs aMED ≥ 6CVD-cause mortality | 3.31 (1.28–8.57) | P = 0.018 | |
| 0.10.31310Hazard ratio (log scale) |
Mortality, VCF (adjusted)
- All-cause mortality HR
- 1.75 (95%CI 1.13-2.73, P = 0.041)
- Cardiovascular disease (CVD)-cause mortality HR
- 2.35 (95%CI 1.12-4.91, P = 0.038)
Moderating effect in subgroups
- Dyslipidemia HR
- 2.49 (95%CI 1.29-4.80, P = 0.009)
- CVD HR
- 3.48 (95%CI 1.56-7.74, P < 0.001)
- CKD HR
- 3.64 (95%CI 1.50-8.78, P < 0.001)
Original publication
Impact of Mediterranean diet on mortality in vertebral compression fracture patients. Arthritis Res Ther. Published 16 April 2025. doi:10.
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