Age at First Fracture and Later Fracture Risk in Older Adults Undergoing Osteoporosis Assessment
Authors' conclusion
In this cohort study, fractures in adulthood were associated with future fractures regardless of the age at which they occurred.
Study context
- Population
- Individuals in the Manitoba bone mineral density (BMD) Registry with a first BMD measurement between January 1, 1996, and March 31, 2018 (mean [SD] age 64.6 [11.0] years; 90.3% female)80,066 [90.3%] female
- Participants
- 88,696 individuals
- Exposure
- Prior fracture in adulthood, stratified by age at first fracture (10-year intervals from 20-29 to ≥80 years), vs no prior fracture
- Prior fracturen = 21,105
- Outcome
- Incident fractures after DXA (index date), identified using linked provincial administrative health data
- Follow-up
- Before March 31, 2021
Methodological detailsobservational, registry-based, sex- and age-adjusted and fully adjusted HRs, Data analysis completed between April 1, and May 31, 2023
- Observational
- Registry-based
- Sex- and age-adjusted and fully adjusted HRs
- Data analysis completed between April 1, and May 31, 2023
Main finding
As reported in the abstract
Sex- and age-adjusted HRs, all significantly elevated across age at first fracture; range of point estimates
1.55 (95% CI, 1.28-1.88) to 4.07 (95% CI, 2.99-5.52)
Fully adjusted HRs, similar and still significantly elevated across age categories; range of point estimates
1.51 (95% CI, 1.42-1.60) to 2.12 (95% CI, 1.67-2.71)
Observational data: associations, not effects.
Further findings
Incident fractures in the whole cohort · mean (SD) 9.0 (5.5) years of follow-up
- Any incident fracture
- 13 239 (14.6%)
- Osteoporotic fractures
- 12 425 (14.0%)
- Major osteoporotic fractures (MOFs)
- 9440 (10.6%)
- Hip fractures
- 3068 (3.5%)
Sensitivity analyses: age at last prior fracture; multiple prior fractures
- Similar results
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →