Systemic sclerosis & Raynaud's
Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis
Authors' conclusion
The histologic features that significantly correlated with Fibrosis Score changes (e.g., hyalinized collagen, SC fat loss) were distinct from those associated with mRSS changes (e.g., telangiectasia and perivascular CD3 +).
Study context
- Population
- Adults with dcSSc ≤ 6 years5 with available biopsies
- Participants
- 10 adults
- Outcome
- Associations of mRSS and AI Fibrosis Score with histologic parameters
- Follow-up
- 0-52 W
Methodological detailssingle-arm, early study termination, Early study termination; biopsies unavailable for 5 due to fixation issues
- Single-arm
- Early study termination
- Early study termination; biopsies unavailable for 5 due to fixation issues
Main finding
As reported in the abstract
0-52 W
- Correlation between Fibrosis Score and modified Rodnan skin score (mRSS) (R; p = 0.674)
- 0.3
- Per 1-unit mRSS change: telangiectasia, OR
- 2.01 (95% CI 1.31-3.07; p 0.001)
- Per 1-unit mRSS change: perivascular CD3 +, OR
- 0.99 (95% CI 0.97-1.02; p 0.015)
- Per 1-unit mRSS change: % of CD8 + among CD3 +, OR
- 0.95 (95% CI 0.89-1.01; p 0.031)
- Per 1-unit Fibrosis Score change: hyalinized collagen, OR
- 1.1 (95% CI 1.04 - 1.16; p < 0.001)
- Per 1-unit Fibrosis Score change: Subcutaneous (SC) fat loss, OR
- 1.47 (95% CI 1.19-1.81; p < 0.001)
- Per 1-unit Fibrosis Score change: thickened intima, OR
- 1.21 (95% CI 1.06-1.38; p 0.005)
- Per 1-unit Fibrosis Score change: eccrine entrapment, OR
- 1.14 (95% CI 1-1.31; p 0.046)
Further findings
| Outcome | Values |
|---|---|
| mRSS change (0-52 W), all enrolled | ten participants Median −2 (IQR −9–7.5) |
| mRSS change (0-52 W), participants with biopsies | five with biopsies Median −2.5 (IQR −11–7.5) |
Original publication
Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis. Arthritis Res Ther. Published 11 April 2025. doi:10.
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