Myeloid dendritic cell subsets characterise muscle in patients with inclusion body myositis and correlate with the IFN-γ pathway and effector T cell markers
Authors' conclusion
Skeletal muscle of patients with IBM is specifically characterised by mDC subsets that correlate with markers of cytotoxic T cells and type 1 inflammation.
Study context
- Population
- Skeletal muscle of patients with inclusion body myositis (IBM), other myositis, and controls
- Comparison
- Skeletal muscle of patients with IBM vs other myositis and controls
- Outcome
- Identification, quantification and characterisation of myeloid dendritic cell subsets (cDC1, conventional dendritic (cDC2), mregDC) and their correlation with markers of IBM disease activity
Methodological detailsSingle-nucleus RNA-sequencing (snRNA-seq) of 3 datasets, bulk RNA-sequencing (RNA-seq) of 2 datasets, immunohistochemistry and immunofluorescence
- snRNA-seq of 3 datasets
- Bulk RNA-seq of 2 datasets
- Immunohistochemistry and immunofluorescence
Main finding
As reported in the abstract
mDC subsets in IBM muscle
- All 3 mDC subsets, especially conventional dendritic (cDC1) cells, relatively increased in IBM muscle
- mDC subsets correlate strongly with IBM-specific inflammatory markers, incl. KLRG1 and TBX21
- cDC1 cells specifically express the KLRG1 ligands CDH1 and CDH2
- cDC1 and mregDC cells express IL12B
Original publication
Myeloid dendritic cell subsets characterise muscle in patients with inclusion body myositis and correlate with the IFN-γ pathway and effector T cell markers. Ann Rheum Dis. Published 6 May 2026. doi:10.
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