Benefits of adjunct plasma exchange in idiopathic inflammatory myopathy with anti-signal recognition particle antibodies: a real-world study
Main findingResult — go to the resultHazard ratio 0.14 CI 0.03–0.57Authors' conclusion
Adjunct PE therapy provided quick remission and sustained benefits for IIM with anti-SRP antibodies.
Study context
- Population
- Anti-SRP-positive idiopathic inflammatory myopathy (IIM) (myositis) patientsmedian follow-up 15 months
- Participants
- 53 participants
- Exposure
- Adjunct plasma exchange (PE) therapy vs standard therapy
- PE therapyn = 18
- Standard therapyn = 35reference
- Outcome
- Composite of:
- All-cause death
- Relapse
Methodological detailsconsecutive enrolment, propensity score matching, inverse probability weighting, real-world
- Consecutive enrolment
- Propensity score matching
- Inverse probability weighting
- Real-world
Main finding
As reported in the abstract
median follow-up 15 months
Hazard ratio
0.14
CI 0.03–0.57
P = 0.006
PE therapyvs Standard therapy
HR 0.14 (CI 0.03–0.57); P = 0.006
- Patients reaching the composite end point
- 26
Observational data: associations, not effects.
Further findings
ILD as predictor of long-term prognosis (multivariate Cox)
| HR (CI) | P value | ||
|---|---|---|---|
| ILDIndependent predictor | 4.82 (1.22–19.12) | P = 0.025 | |
| 0.050.21520Hazard ratio (log scale) |
| Outcome | P value |
|---|---|
| Changes in the six core set measures · 4 weeksChanges more prominent in PE therapy | all P < 0.001 |
Changes in the six core set measures · 4 weeks
- Both groups achieved remarkable remission with significant improvements in the six core set measures (CSMs)
Original publication
Benefits of adjunct plasma exchange in idiopathic inflammatory myopathy with anti-signal recognition particle antibodies: a real-world study. Rheumatology (Oxford). Published 26 April 2026. doi:10.
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