Multiple DMARD discontinuations in rheumatoid arthritis: how often and in what patients? Results from a national clinical rheumatoid arthritis (RA) register
Authors' conclusion
Applying treatment discontinuation-based definitions to an unselected RA population identifies widely varying proportions of patients with largely similar characteristics.
Study context
- Population
- Patients diagnosed with RA between 2010 and 2019, Swedish Rheumatology Quality Register
- Participants
- 17,780 / 18,038 / 8,075
- Exposure
- Newly diagnosed vs First-ever DMARD vs First-ever b/tsDMARD
- Newly diagnosedn = 17,780
- First-ever DMARDn = 18,038
- First-ever b/tsDMARDn = 8,075
- Outcome
- Occurrence of b/tsDMARD discontinuations by seven alternative discontinuation criteria
Methodological detailsnational register (Swedish Rheumatology Quality Register)
- National register (Swedish Rheumatology Quality Register)
Main finding
As reported in the abstract
Discontinued ≥2 b/tsDMARDs with different modes of action · 4.5 years
Observational data: associations, not effects.
Original publication
Multiple DMARD discontinuations in rheumatoid arthritis: how often and in what patients? Results from a national clinical RA register. RMD Open. Published 15 October 2025. doi:10.
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