Autoinflammatory & rare systemic diseases
Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease
Authors' conclusion
Hypocomplementaemia in IgG4-RD is not unique to patients with renal involvement and may reflect the extent of disease. IgG1 independently correlates with hypocomplementaemia in IgG4-RD, but IgG4 does not.
Study context
- Population
- Patients fulfilling the IgG4-related disease (IgG4-RD) classification criteria
- Participants
- 279 patients
- Exposure
- Factors associated with hypocomplementaemia in IgG4-RD
- Outcome
- IgG4-RD features associated with hypocomplementaemia
Methodological detailssingle-centre, unadjusted and multivariable-adjusted logistic regression
- Single-centre
- Unadjusted and multivariable-adjusted logistic regression
Main finding
As reported in the abstract
- Hypocomplementaemia prevalence
- 90 (32%)
- Number of organs involved, unadjusted OR
- 1.42 (1.23 to 1.63) (95% CI)
- Lymph node involvement, unadjusted OR
- 3.87 (2.19 to 6.86) (95% CI)
- Lung involvement, unadjusted OR
- 3.81 (2.10 to 6.89) (95% CI)
- Pancreas involvement, unadjusted OR
- 1.66 (1.001 to 2.76) (95% CI)
- Liver involvement, unadjusted OR
- 2.73 (1.17 to 6.36) (95% CI)
- Kidney involvement, unadjusted OR
- 2.48 (1.47 to 4.18) (95% CI)
- Lymph node involvement, OR adjusted for age, sex, number of organs
- 2.59 (1.36 to 4.91) (95% CI)
- Lung involvement, adjusted OR
- 2.56 (1.35 to 4.89) (95% CI)
- Renal involvement, adjusted OR (95% CI) (attenuated)
- 1.6 (0.92 to 2.98)
- Fibrotic disease manifestations, adjusted OR (95% CI) (inverse)
- 0.43 (0.21 to 0.87)
- Lacrimal gland involvement, adjusted OR (95% CI) (inverse)
- 0.53 (0.28 to 0.999)
Observational data: associations, not effects.
Further findings
Immunoglobulin concentrations and hypocomplementaemia
- Hypocomplementaemia associated with higher concentrations of all IgG subclasses and IgE
- all p<0.05
- After adjusting for serum IgG1 and IgG3, only IgG1 but not IgG4 remained strongly associated with hypocomplementaemia
Original publication
Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease. Ann Rheum Dis. Published 14 November 2024. doi:10.
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