Autoinflammatory & rare systemic diseases
Defining pancreatic damage and symptom burden in IgG4-related autoimmune pancreatitis: A cross-sectional study of 118 patients from a single-center registry
Authors' conclusion
Despite an often subclinical presentation, autoimmune pancreatitis is associated with EPI, DM, or both in a high percentage of patients with IgG4-RD.
Study context
- Population
- Patients fulfilling the ACR/EULAR IgG4-related disease (IgG4-RD) Classification Criteria, single-centre registry162 completed surveys
- Participants
- 303 patients
- Exposure
- Patients with vs without autoimmune pancreatitis
- Autoimmune pancreatitisn = 118
- Outcome
- Pancreatic damage in autoimmune pancreatitis
Methodological detailssingle-centre registry
- Single-centre registry
Main finding
As reported in the abstract
- Autoimmune pancreatitis among IgG4-RD patients
- 118 (39 %)
- Diabetes mellitus (DM)
- 47 %
- Exocrine pancreatic insufficiency (EPI)
- 48 %
- Both DM and EPI
- 21 %
- Overt indicators of acute pancreatitis (e.g., abdominal pain, nausea/emesis, elevated serum lipase), each
- fewer than 50 %
Observational data: associations, not effects.
Further findings
Low fecal elastase concentrations
- Stool samples with low elastase
- 40/49 (82 %)
Pancreatic resection before diagnosis
- Patients with resection
- 9/118 (8 %)
Patient-reported symptom burden (survey)
- Higher burden of abdominal pain, weight loss and changes in stool with vs without autoimmune pancreatitis
- all p < 0.05
- 162/325 (50 %) completed surveys; n = 81 [50 %] with autoimmune pancreatitis
Original publication
Defining pancreatic damage and symptom burden in IgG4-related autoimmune pancreatitis: A cross-sectional study of 118 patients from a single-center registry. Semin Arthritis Rheum. Published 21 May 2025. doi:10.
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