Autoinflammatory & rare systemic diseases
Predictors of irreversible renal dysfunction in patients with idiopathic retroperitoneal fibrosis
Authors' conclusion
A prognostic score based on factors including CD19+ B cells <9.3% and sCr ≥120 µmol/L at baseline, and no response at 6 months, is suitable for predicting irreversible renal dysfunction in iRPF.
Study context
- Population
- Patients with newly diagnosed idiopathic retroperitoneal fibrosis (iRPF), Zhongshan Hospital of Fudan University, January 2010–September 2022
- Participants
- 83 patients
- Comparison
- Training set vs Validation set
- Training setn = 60
- Validation setn = 23
- Outcome
- Predictors of irreversible renal dysfunction
Methodological detailscohort with training and validation sets, single-centre, univariate and multivariate regression, logistic model, ROC analysis
- Cohort with training and validation sets
- Single-centre
- Univariate and multivariate regression
- Logistic model
- ROC analysis
Performance
As reported in the abstract
Prediction of irreversible renal dysfunction by prognostic score ≥2 (1 point CD19+ B cells <9.3%, 1 point serum creatinine (sCr) ≥120 µmol/L, 2 points no response at 6 months)
Training set: sensitivity of score ≥2
100%
Training set: specificity of score ≥2
92%
Validation set: sensitivity
100%
Validation set: specificity
94.4%
Further findings
- Estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m² at last follow-up · median follow-up 29 months — Training set
- 16.7%
- Hydronephrosis or prolonged double-J stents · median follow-up 29 months — Training set
- 25%
- Irreversible renal dysfunction — Validation set
- 21.7%
Original publication
Predictors of irreversible renal dysfunction in patients with idiopathic retroperitoneal fibrosis. Rheumatology (Oxford). Published 26 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →