Autoinflammatory & rare systemic diseases
Autoantibody reactome analysis reveals novel biomarkers for idiopathic retroperitoneal fibrosis
Authors' conclusion
This study identified five autoantibodies with diagnostic potential for iRPF, providing a novel basis for early detection, disease monitoring and further mechanistic investigations.
Study context
- Population
- Patients with idiopathic retroperitoneal fibrosis (iRPF), healthy controls, retroperitoneal sarcoma (RPS) and other autoimmune diseases, Renji Hospital, January 2018 to April 2025
- Participants
- 33 / 100 / 11 / 74
- Comparison
- iRPF vs healthy controls, RPS and other autoimmune diseases
- iRPFn = 33
- Healthy controlsn = 100reference
- RPSn = 11
- Other autoimmune diseasesn = 74
- Outcome
- Novel autoantibodies for diagnosis and differential diagnosis of iRPF
Methodological detailssingle-centre, autoantibody screening by protein array, enzyme-linked immunosorbent assay (ELISA) and dot blot validation, ROC curve analysis
- Single-centre
- Autoantibody screening by protein array
- ELISA and dot blot validation
- ROC curve analysis
Performance
As reported in the abstract
Plasma autoantibody levels, iRPF vs healthy controls
- Anti-RBPJ, anti-TPM1, anti-C1D, anti-NPM1 and anti-IL-1A autoantibodies significantly elevated in iRPF vs healthy controls
Further findings
| Outcome | iRPF | P value |
|---|---|---|
| Anti-C1D antibodies, iRPF vs RPS discrimination | P < 0.01 | |
| AUC | 0.718 |
Anti-TPM1 antibody correlations
- Positive correlation with hydronephrosis severity
- P < 0.05
- Positive correlation with serum creatinine
- P < 0.01
- Declined after treatment
Anti-RBPJ antibodies
- Increased after treatment
- P < 0.01
- Negative correlation with IL-6
- P < 0.05
Anti-C1D antibodies, iRPF vs RPS discrimination
- Anti-C1D IgG4 subclass associated with Th1/Th2 imbalance and renal impairment
Anti-NPM1 IgG4/IgG ratio
- Positively correlated with renal injury markers and Th2-type cytokines
Original publication
Autoantibody reactome analysis reveals novel biomarkers for idiopathic retroperitoneal fibrosis. Rheumatology (Oxford). Published 28 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →