Spondyloarthritis & psoriatic arthritis
Multimodal imaging of structural damage and inflammation in psoriatic arthritis: a comparison of DMARD-naive and DMARD-failure patients
Authors' conclusion
At baseline, PsA patient groups were comparable concerning structural and inflammatory imaging parameters, especially after correcting for patient characteristics.
Study context
- Population
- Patients with active PsA meeting classification criteria, minimum disease duration of eight weeks, first cohort of the multicentre TOFA-PREDICT trial
- Participants
- 80 patients
- Exposure
- DMARD-naive vs DMARD-failure PsA patients
- DMARD-naiven = 40reference
- DMARD-failuren = 40
- Outcome
- Inflammatory and structural imaging parameters (radiographs of hands and feet, MRI of both ankles, whole-body 18F-FDG PET/CT; incl. SHS, HEMRIS, Deauville synovitis score)
- Follow-up
- Baseline
Methodological detailsbaseline analysis of the multicentre TOFA-PREDICT trial, multiple linear regression
- Baseline analysis of the multicentre TOFA-PREDICT trial
- Multiple linear regression
Main finding
As reported in the abstract
- Inflammatory imaging parameters not significantly different
- P > 0.200
- HEMRIS Achilles tendon structural damage significantly different, higher in DMARD failures
- P = 0.024, R2 = 0.071
- SHS Joint Space Narrowing not statistically significant, higher in DMARD failures
- P = 0.050, R2 = 0.048
- After correction for patient characteristics, these differences disappeared
- both P > 0.600
Observational data: associations, not effects.
Original publication
Multimodal imaging of structural damage and inflammation in psoriatic arthritis: a comparison of DMARD-naive and DMARD-failure patients. Rheumatology (Oxford). Published 17 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →