MRI-defined tissue damage as predictors of the incidence and progression of knee osteoarthritis: A systematic review
Authors' conclusion
Several MRI-detected joint tissue pathologies longitudinally associated with structural progression and clinically relevant outcomes, such as total knee arthroplasty, allowing patient stratification for disease-modifying osteoarthritis drug (DMOAD) trials.
Study context
- Population
- Studies of MRI-detected joint tissue pathology predicting knee OA incidence and progression (PubMed, Scopus, Web of Science)99 studies
- Outcome
- Prediction of radiographic progression and longitudinal evolution of clinical outcomes and functional decline by MRI-detected joint tissue pathology
Methodological detailsqualitative synthesis, quality assessed with Newcastle-Ottawa Scale and Downs and Black checklist
- Qualitative synthesis
- Quality assessed with Newcastle-Ottawa Scale and Downs and Black checklist
Pooled result
As reported in the abstract
Baseline cartilage T2 signal abnormalities predicted new structural cartilage defects
OR 21.3
95% CI 11.1, 40.6
Original publication
MRI-defined tissue damage as predictors of the incidence and progression of knee osteoarthritis: A systematic review. Semin Arthritis Rheum. Published 13 May 2026. doi:10.
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