Lupus & antiphospholipid syndrome
Mortality patterns of SLE and the associated risk factors in Korean patients: a nationwide cohort study
Authors' conclusion
Among Korean patients with SLE, SLE-related conditions were the leading causes of mortality. However, CVD and cancer were also identified as the main causes of mortality. Furthermore, pulmonary manifestations were significantly associated with SLE-related mortality.
Study context
- Population
- Korean patients aged 10–79 years with incident SLE, National Health Insurance database 2008–2018 (mean age 42.3±16.7 years; 86.1% female)
- Participants
- 11,375 patients57,658 person-years (PYs)
- Exposure
- Men vs Women
- Outcome
- All-cause and cause-specific mortality (MR, deaths per 100 000 PYs)
Methodological detailsNational Health Insurance database 2008–2018, generalised estimating equation model
- National Health Insurance database 2008–2018
- Generalised estimating equation model
Main finding
As reported in the abstract
All-cause mortality
- Deaths, all patients
- 728
- Overall mortality rate (MR) (/100 000 PYs)
- 1262.62
Observational data: associations, not effects.
Further findings
Leading causes of death (MR /100 000 PYs)
- SLE-related conditions
- 381.56
- Cardiovascular disease (CVD)
- 202.92
- Cancer
- 175.17
- Infection
- 143.95
Risk factors for SLE-related mortality
- Pulmonary alveolar haemorrhage, OR
- 9.93
- PAH, OR
- 3.77
- ILD, OR
- 3.27
Original publication
Mortality patterns of SLE and the associated risk factors in Korean patients: a nationwide cohort study. Lupus Sci Med. Published 26 February 2025. doi:10.
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