Mortality in patients with incident rheumatoid arthritis and depression: a Danish cohort study of 11 071 patients and 55 355 comparators
Main finding · All-cause mortalityResult — go to the resultAdjusted HRR 3.15 95% CI 2.62–3.79Authors' conclusion
In patients with RA, depression was a predictor of death but with a strength similar to that in matched comparators.
Study context
- Population
- Patients with incident RA in the nationwide Danish rheumatologic database DANBIO, 2008–2018, and five randomly selected background population comparators each; no antidepressants or depression 3 years before index date
- Exposure
- Depression vs no depression, in patients with incident RA and in background population comparators
- Outcome
- All-cause mortality
Methodological detailsnationwide, matched comparators (five per patient), Cox regression
- Nationwide
- Matched comparators (five per patient)
- Cox regression
Main finding
As reported in the abstract
total follow-up
Adjusted hazard rate ratios (HRR)
3.15
95% CI 2.62–3.79
Observational data: associations, not effects.
Further findings
| Outcome | HRR (95% CI) | |
|---|---|---|
| All-cause mortality, patients <55 years (subgroup)Depressed RAvs RA without depression | 8.13 (3.89–17.02) | |
| 0.050.21520Hazard rate ratios (log scale) |
| Outcome | Adjusted HRR (95% CI) |
|---|---|
| All-cause mortality · 0-2 yearsDepressed RA vs RA without depression | 5.34 (3.02–9.45) |
Causes of death in depressed RA
- No unnatural causes of death
- Most frequent natural causes: cancer, CVD, stroke and pneumonia
Original publication
Mortality in patients with incident rheumatoid arthritis and depression: a Danish cohort study of 11 071 patients and 55 355 comparators. Rheumatology (Oxford). Published 30 May 2023. doi:10.
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