More severe parotid gland histopathology in paediatric-onset than in adult-onset Sjögren’s disease
Authors' conclusion
Patients with pedSjD exhibit more pronounced histopathological features compared with patients with adSjD at diagnosis.
Study context
- Population
- Patients with pedSjD or adSjD with a baseline parotid gland biopsy, Groningen, the Netherlands
- Participants
- 19 / 32 / 42
- Exposure
- Parotid gland histopathology in pedSjD vs adSjD
- pedSjDn = 19
- Diagnostic adSjDn = 32reference
- Trial adSjDn = 42
- Outcome
- SjD-related histopathological markers in parotid gland biopsies after (immuno)histological staining
Methodological detailssingle-centre (Groningen, the Netherlands), three cohorts: diagnostic paediatric, diagnostic adult, clinical trial adult
- Single-centre (Groningen, the Netherlands)
- Three cohorts: diagnostic paediatric, diagnostic adult, clinical trial adult
Main finding
As reported in the abstract
Parotid gland histopathology, pedSjD vs diagnostic adSjD (comparable total EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI))
- All characteristic histopathological features of adSjD also observed in pedSjD
- No significant differences in lymphoepithelial lesions or immunoglobulin A (IgA)/IgG plasma cell shift between pedSjD and adSjD cohorts
- pedSjD vs Diagnostic adSjD: P = 0.003
- pedSjD vs Diagnostic adSjD: P = 0.041
- pedSjD vs Diagnostic adSjD: P = 0.004
- pedSjD vs Diagnostic adSjD: P = 0.029
- pedSjD vs Diagnostic adSjD: P = 0.013
- pedSjD vs Diagnostic adSjD: P = 0.029
- pedSjD vs Diagnostic adSjD: P = 0.002
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Parotid gland histopathology, pedSjD vs trial adSjDTrial adSjD vs pedSjD | P = 0.001 |
| Parotid gland histopathology, pedSjD vs trial adSjDpedSjD vs Trial adSjD | P = 0.023 |
| Parotid gland histopathology, pedSjD vs trial adSjDpedSjD vs Trial adSjD | P = 0.018 |
Parotid gland histopathology, pedSjD vs trial adSjD
- Only B/T lymphocyte ratio and germinal centres (GC)/mm² significantly higher in pedSjD
Original publication
More severe parotid gland histopathology in paediatric-onset than in adult-onset Sjögren’s disease. RMD Open. Published 13 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →