Increased vascular deposition of oxidized low-density lipoprotein (LDL) in untreated juvenile dermatomyositis
Main finding · oxLDL deposition in muscle vessel wallsResult — go to the resultDifference in means 19.86Authors' conclusion
This study found increased deposition of oxLDL within blood vessels of children with untreated JDM supporting the concern that these children are at increased risk for premature atherosclerosis from chronic exposure to vascular oxLDL.
Study context
- Population
- Female children with untreated juvenile dermatomyositis (JDM) and female pediatric controls; frozen sections of MRI-directed muscle biopsies
- Participants
- 20 vs 5
- Exposure
- Untreated JDM vs healthy pediatric controls
- Untreated JDMn = 20
- Controlsn = 5reference
- Outcome
- Deposition of oxLDL (total fluorescence) in the walls of muscle vasculature
Methodological detailscase-control comparison, immunofluorescence of MRI-directed muscle biopsies
- Case-control comparison
- Immunofluorescence of MRI-directed muscle biopsies
Main finding
oxLDL deposition in muscle vessel walls
Difference in means
19.86
P = 0.03
As reported in the abstract
Observational data: associations, not effects.
Further findings
oxLDL deposition vs duration of untreated disease (within JDM)
- Trend towards increased oxLDL deposition with longer untreated disease, r
- 0.43
- P
- P = 0.06
oxLDL deposition vs markers of acute disease activity (disease activity scores, muscle enzymes)
- No significant correlation
Original publication
Increased vascular deposition of oxidized LDL in untreated juvenile dermatomyositis. Pediatr Rheumatol Online J. Published 8 August 2024. doi:10.
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