Exploring the association between serum Vitamin D levels and the development of coronary artery lesions in Kawasaki disease - a systematic review
Authors' conclusion
Overall, the evidence is inconclusive, but there's a trend suggesting potential benefits of sufficient vitamin D levels in Kawasaki disease rather than evidence refuting any association with clinical outcomes.
Study context
- Population
- Patients with Kawasaki disease and healthy controls5 studies
- Participants
- 442 vs 594
- Comparison
- Kawasaki Disease (KD) patients vs healthy controls; serum vitamin D and coronary artery lesions (CAL)
- KDn = 442
- Healthy controlsn = 594reference
- Outcome
- Association between serum vitamin D levels and CAL in KD
Methodological detailsNewcastle-Ottawa Scale quality assessment, four databases (PubMed, Embase, Scopus, Web of Science)
- Newcastle-Ottawa Scale quality assessment
- Four databases (PubMed, Embase, Scopus, Web of Science)
Pooled result
As reported in the abstract
- CAL: one study found lower vitamin D, another found higher levels associated with CAL, and two found no significant difference
- Mixed findings on association with CAL and IVIG resistance
Further pooled results
- KD patients generally had lower serum vitamin D vs controls; 3 studies supported lower vitamin D in KD, one showed no significant difference
Original publication
Exploring the association between serum Vitamin D levels and the development of coronary artery lesions in Kawasaki disease - a systematic review. Pediatr Rheumatol Online J. Published 5 August 2024. doi:10.
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