Monozygotic twins discordant for juvenile dermatomyositis: clinical, serological and gene expression studies
Authors' conclusion
JDM twins (and two of the non-JDM twins) had significantly lower nailfold capillary ERL and decreased serum endoglin levels compared to healthy controls.
Study context
- Population
- Monozygotic twins discordant for Juvenile Dermatomyositis (JDM)5 twin pairs
- Comparison
- JDM twins vs non-JDM co-twins and healthy controls
- Outcome
- Gene expression differences between monozygotic twins discordant for JDM
Methodological detailsmonozygotic twins discordant for JDM
- Monozygotic twins discordant for JDM
Main finding
As reported in the abstract
- RNASeq (3 twin pairs): four genes differentially expressed between JDM and non-JDM twins: DCD, KRT14, COL1A1, COL3A1
- JDM twin had significantly lower nailfold capillary end row loops (ERL) than healthy control; two non-JDM twins also had decreased ERL
- Serum endoglin significantly lower in both JDM and non-JDM twins than in healthy control
Original publication
Monozygotic twins discordant for juvenile dermatomyositis: clinical, serological and gene expression studies. Pediatr Rheumatol Online J. Published 26 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →