Fibromyalgia & musculoskeletal pain
Mitochondrial structural alterations in fibromyalgia: a pilot electron microscopy study
Authors' conclusion
We describe novel morphological changes in mitochondria of FM patients, including loss of mitochondrial cristae.
Study context
- Population
- Fibromyalgia (FM) patients from a specialised Fibromyalgia Clinic at a tertiary medical centre and healthy controls
- Comparison
- FM patients vs healthy controls
- Outcome
- Structural changes in mitochondria of peripheral blood mononuclear cells (PBMCs), by transmission electron microscopy (TEM)
Methodological detailspilot, transmission electron microscopy
- Pilot
- Transmission electron microscopy
Main finding
As reported in the abstract
Mitochondrial structure in PBMCs (TEM)
- Several distinct mitochondrial cristae patterns, including total loss of cristae in FM patients
- Number of mitochondria with intact cristae morphology reduced in FM patients
- Percentage of mitochondria completely lacking cristae increased in FM patients
- These results correlated with widespread pain index (WPI) severity
- High percentage of cells containing electron dense aggregates (possibly ribosome aggregates) in FM samples
- Cristae loss and possible ribosome aggregation were intercorrelated
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Mitochondrial structural alterations in fibromyalgia: a pilot electron microscopy study. Clin Exp Rheumatol. Published 30 March 2024. doi:10.
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