Microvascular status and skin thickness in adults with hypermobile Ehlers-Danlos syndrome: a pilot investigation
Authors' conclusion
Our study detected in hEDS patients a normal microvascular function at rest and a suitable capillary morphology but with increased microvascular fragility. The dermal thickness seems thinner in hEDS patients than in controls in most skin areas, with strong statistically significance at the level of feet and thorax.
Study context
- Population
- Adults with hypermobile Ehlers-Danlos syndrome and sex- and age-matched controls
- Comparison
- Hypermobile Ehlers-Danlos Syndrome (hEDS) vs sex- and age-matched controls
- Outcome
- Microvascular morphology (nailfold videocapillaroscopy (NVC)), peripheral blood perfusion (laser speckle contrast analysis (LASCA)) and dermal thickness (high-frequency skin US, 22 MHz)
Methodological detailspilot, sex- and age-matched controls
- Pilot
- Sex- and age-matched controls
Main finding
As reported in the abstract
Microvascular morphology, perfusion and dermal thickness
- Microhaemorrhages more prevalent in hEDS than controls
- Nailfold capillary number per linear mm slightly higher and abnormal-shaped capillary score slightly lower in hEDS, not statistically significant
- Peripheral blood perfusion (PBP) comparable between hEDS and controls
- Dermal thickness (DT) generally lower in hEDS than controls
- hEDS vs Controls: P = 0.04
Observational data: associations, not effects.
Further findings
Correlation of Beighton score with microhaemorrhage score
- Positive correlation, r
- 0.4
- P
- P = 0.05
Correlation of Beighton score with DT at feet and thorax
- Positive correlation, r
- ≥0.5
- P
- P ≤ 0.02
Original publication
Microvascular status and skin thickness in adults with hypermobile Ehlers-Danlos syndrome: a pilot investigation. Clin Exp Rheumatol. Published 13 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →