Associations between serological biomarkers and subclinical atherosclerosis in patients with rheumatoid arthritis after 11 years of follow-up
Authors' conclusion
Among these patients with RA GDF-15 was associated to cIMT after 11 years of follow-up.
Study context
- Population
- Patients under 60 years with newly diagnosed RA, northern region of Sweden, included 2000–2004
- Exposure
- Patients with RA vs controls
- RAn = 54
- Outcome
- Association of biomarkers with subclinical atherosclerosis measured by cIMT
- Follow-up
- T11 (11 years )
Methodological detailslongitudinal follow-up at T0, T5 and T11, linear regression
- Longitudinal follow-up at T0, T5 and T11
- Linear regression
Main finding
As reported in the abstract
cIMT at T11 and GDF-15
- Carotid intima media thickness (cIMT) at T11 associated with GDF-15 levels at T5 and T11, but not with baseline levels
- Change in GDF-15 from T0 to T11 associated with an increase in cIMT at T11 (multivariable)
- Adjusting for systolic blood pressure and age respectively rendered this association statistically non-significant
Observational data: associations, not effects.
Further findings
GDF-15 levels, RA vs controls · T11
- Mean GDF-15 elevated in RA vs controls; GDF-15 strongly associated with age
Adiponectin, MCP-1, cathepsin S, endoglin and IL-6
- Higher in RA vs controls, but no association with cIMT
Original publication
Associations between serological biomarkers and subclinical atherosclerosis in patients with rheumatoid arthritis after 11 years of follow-up. Clin Exp Rheumatol. Published 9 June 2023. doi:10.
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