Matrix metalloproteinase-12, an indicator potentially contributing to the differential diagnosis and activity assessment of retroperitoneal fibrosis
Authors' conclusion
The positive rate of MMP-12 in the GCs of pathological tissues is a potential marker that contributes to the differential diagnosis of RPF and might be associated with the degree of fibrosis, although MMP-12 in the peripheral blood was not very helpful for disease diagnosis and monitoring of treatment effects.
Study context
- Population
- Patients with retroperitoneal fibrosis (RPF)
- Comparison
- MMP-12 positive rate in pathological tissues of RPF vs healthy controls
- Outcome
- Positive rate of MMP-12 in pathological tissues for differential diagnosis of RPF
Performance
As reported in the abstract
Diagnostic performance of the tissue MMP-12 positive rate for RPF
- Positive rate of MMP-12 in pathological tissues significantly higher than in healthy controls
Further findings
Correlations of tissue MMP-12 positive rate
- Positively correlated with positive rates of mTOR, CXCR5, IL-13 in germinal centres (GCs) and MMP-12, IL-13 in the periphery
- Thickness of RPF mass more severe in MMP-12 positive group (by cut-off)
MMP-12 concentration in peripheral blood
- Did not increase significantly; positively correlated with time before treatment and CXCR5 positive rate in GCs
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Matrix metalloproteinase-12, an indicator potentially contributing to the differential diagnosis and activity assessment of retroperitoneal fibrosis. Clin Exp Rheumatol. Published 11 October 2024. doi:10.
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