Fibromyalgia & musculoskeletal pain
Lower circulating IGF-1 levels in fibromyalgia: meta-analysis highlighting potential pathogenic role
Pooled result · IGF-1 levelsResult — go to the resultSMD −0.347 95% CI −0.747 to 0.053Authors' conclusion
Our meta-analysis demonstrated that IGF-1 levels were significantly lower in patients with FM
Study context
- Population
- Patients with fibromyalgia (FM) and healthy controls; serum/plasma IGF-1 levels12 studies from 11 reports
- Participants
- 512 vs 308
- Comparison
- FM vs healthy controls
- FMn = 512
- Controlsn = 308reference
- Outcome
- Circulating (serum/plasma) IGF-1 levels
Methodological detailssubgroup analyses by region, sample size, data type, publication year and matched variables, sensitivity analysis, publication bias adjustment
- Subgroup analyses by region, sample size, data type, publication year and matched variables
- Sensitivity analysis
- Publication bias adjustment
Pooled result
IGF-1 levels
SMD
−0.347
95% CI −0.747 to 0.053
P = 0.089
FMvs Controls
SMD −0.347 (95% CI −0.747 to 0.053); P = 0.089
As reported in the abstract
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| IGF-1 levels, studies with original data (subgroup)Significantly lower IGF-1 level in FM | −0.458 (−0.857 to −0.060) | P = 0.024 | |
| IGF-1 levels, recent publication year (year >2012) (subgroup)Significantly lower IGF-1 level in FM | −0.679 (−1.066 to −0.293) | P = 0.001 | |
| −1.5−1−0.500.5Difference (linear scale) |
IGF-1 levels, sensitivity analysis (one study significantly affected the pooled SMD)
- Pooled SMD after sensitivity analysis
- SMD =−0.458, 95% CI: −0.822 to −0.093, p=0.014
- Results of this meta-analysis were unstable
IGF-1 levels, adjusted for publication bias
- SMD changed to be significant after adjusting for publication bias
- SMD =−0.513, 95% CI: −0.924 to −0.102
Original publication
Lower circulating IGF-1 levels in fibromyalgia: meta-analysis highlighting potential pathogenic role. Clin Exp Rheumatol. Published 4 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →