Maternal weight and hypertension as risk factors for juvenile idiopathic arthritis: a prospective population-based pregnancy cohort study
Authors' conclusion
Higher GWG and HDPs were independently associated with increased JIA risk.
Study context
- Population
- Children in the Norwegian Mother, Father and Child Cohort Study (MoBa); all ≥14 years old at end of follow-up265 developed juvenile idiopathic arthritis (JIA)
- Participants
- 78,901 children
- Exposure
- Maternal prepregnancy body mass index (BMI), gestational weight gain (GWG) and HDP vs their absence or lower levels
- Outcome
- JIA in children
Methodological detailslinked to Norwegian Patient Registry, logistic regression, causal mediation analyses, genotyped subsample Polygenic Risk Score (PRS) interaction
- Linked to Norwegian Patient Registry
- Logistic regression
- Causal mediation analyses
- Genotyped subsample PRS interaction
Main finding
As reported in the abstract
JIA by maternal exposure
Adjusted odds ratio (95% CI)
Each 1 SD (≈6 kg) increase in GWG
1.12(1.00–1.26)
Maternal hypertension
1.43(1.02–1.99)
Pre-eclampsia
1.61(1.10–2.37)
Each 1 SD, as printed
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| GWG and JIA among women with prepregnancy obesity (subgroup) | 1.40 (1.10–1.77) | |
| 0.512Adjusted odds ratio (log scale) |
Maternal obesity and JIA among children with lower PRS (genotyped subsample)
| aOR (95% CI) | ||
|---|---|---|
| Maternal obesity | 0.37 (0.17–0.80) | |
| 0.10.31310Adjusted odds ratio (log scale) |
- Maternal obesity and JIA among children with lower PRS (genotyped subsample): genotyped subsample: 192 JIA/44 053 non-JIA
Mediation of GWG-JIA association by hypertension
- Hypertension did not mediate the GWG-JIA association
- P > 0.05
Original publication
Maternal weight and hypertension as risk factors for juvenile idiopathic arthritis: a prospective population-based pregnancy cohort study. RMD Open. Published 30 July 2026. doi:10.
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