Spondyloarthritis & psoriatic arthritis
Lung involvement in psoriatic arthritis patients: cross-sectional study on prevalence, clinical characteristics, and risk factors of a neglected comorbidity
Authors' conclusion
Our data support the hypothesis of a correlation between PsA and LDs highlighting that non-traditional risk factors may contribute to the development of LDs in PsA patients, especially in cases of uncontrolled, active articular disease.
Study context
- Population
- Patients with PsA from three Italian centres, chest high-resolution CT before start of bDMARD
- Participants
- 322 patients
- Exposure
- PsA with chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD) vs PsA without lung disease
- COPDn = 39
- ILDn = 27
- Outcome
- Lung involvement (prevalence of lung diseases) and its risk factors in PsA
Methodological detailsmulticentre (three Italian centres), chest high-resolution CT before start of bDMARD, univariate and multivariate analysis
- Multicentre (three Italian centres)
- Chest high-resolution CT before start of bDMARD
- Univariate and multivariate analysis
Main finding
As reported in the abstract
Prevalence of lung disease
Observational data: associations, not effects.
Further findings
Risk factors for COPD
| OR | P value | |
|---|---|---|
| DAPSA>14 | 4.3 | p.adj=0.03 |
| SJC>3 | 3.2 | p.adj=0.02 |
| PASI>10 | 3.6 | p.adj=0.008 |
| BMI ≥30 | 3 | p.adj=0.04 |
| Outcome | Estimate | P value |
|---|---|---|
| Risk factors for COPDOld age (≥65 years) | increased risk up to (times) 9.6 | p.adj=0.004 |
| Risk factors for ILDSJC>3 · just SJC emerged as a risk factor for ILD | OR 3 | p.adj=0.04 |
| Risk factors for ILDOld age (≥65 years) · just SJC emerged as a risk factor for ILD | increased risk up to (times) 7.6 | p.adj=0.04 |
Original publication
Lung involvement in psoriatic arthritis patients: cross-sectional study on prevalence, clinical characteristics, and risk factors of a neglected comorbidity. Clin Exp Rheumatol. Published 20 January 2025. doi:10.
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