Systemic sclerosis & Raynaud's
Lung imaging patterns in connective tissue disease–associated interstitial lung disease impact prognosis and immunosuppression response
Authors' conclusion
NSIP and OP were associated with better outcomes and response to immunosuppression, while fHP had worse survival compared with UIP.
Study context
- Population
- Patients with CTD-ILD (most frequent: SSc n = 215, RA n = 127, inflammatory myopathies n = 100)
- Participants
- 645 patients
- Exposure
- HRCT imaging patterns vs usual interstitial pneumonia (UIP)
- Outcome
- Transplant-free survival and change in percent-predicted FVC
Methodological detailsHRCT reviewed by expert radiologists blinded to clinical data, Cox and linear mixed-effects models adjusted for age, sex, smoking and baseline forced vital capacity (FVC)
- HRCT reviewed by expert radiologists blinded to clinical data
- Cox and linear mixed-effects models adjusted for age, sex, smoking and baseline FVC
Main finding
As reported in the abstract
Each group vs UIPHazard ratio (mortality) (95% CI)
NSIP
0.65(0.45–0.93)
OP
0.18(0.05–0.57)
fHP
1.58(1.01–2.40)
Slower FVC decline, %/year
- Non-specific interstitial pneumonia (NSIP)
- 1.1 (95% CI 0.2–1.9)
- Organizing pneumonia (OP)
- 3.5 (95% CI 2.0–4.9)
Observational data: associations, not effects.
Further findings
| Outcome | Slower FVC decline (%/year) (95% CI) |
|---|---|
| FVC decline after immunosuppression vs pre-treatment | 2.1 (1.4–2.8) |
Extent of fibrosis
- The extent of fibrosis also predicted FVC decline and mortality
FVC decline after immunosuppression vs pre-treatment
- No change for UIP or fibrotic hypersensitivity pneumonitis (fHP)
Original publication
Lung imaging patterns in connective tissue disease–associated interstitial lung disease impact prognosis and immunosuppression response. Rheumatology (Oxford). Published 9 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →