Lung function trajectory of rheumatoid arthritis–associated interstitial lung disease
Authors' conclusion
Most patients with RA-ILD experienced stable or slowly declining lung function. In 5% of patients, predicted FVC% deteriorated rapidly, especially in older adults with early RA. The lung function trajectory was not comparable to the RA disease activity trajectory.
Study context
- Population
- Patients with RA-ILD in the Korean RA-ILD cohort, followed up annually for 3 years≥2 pulmonary function tests
- Participants
- 140 patients
- Exposure
- Improving vs Stable vs Slowly declining vs Rapidly declining
- Improvingn = 11
- Stablen = 68
- Slowly decliningn = 54
- Rapidly decliningn = 7
- Outcome
- Trajectory of predicted FVC%
- Follow-up
- 3 years
Methodological detailsmulticentre, prospective observational cohort, group-based trajectory modelling
- Multicentre
- Prospective observational cohort
- Group-based trajectory modelling
Main finding
As reported in the abstract
Predicted FVC% trajectories
Observational data: associations, not effects.
Further findings
RA disease activity
- Maintained or improved to low RA disease activity
- 77.7%
- Lung function trajectory not comparable to RA disease activity trajectory
Predictors of rapidly declining predicted FVC%
- Age ≥70 years, RR
- 10.8 (95% CI 1.30, 89.71)
- Early RA diagnosed within the preceding 2 years, RR
- 10.1 (95% CI 1.22, 84.2)
Predictors of deterioration or mortality
- Simultaneous diagnosis of RA and ILD within 24 weeks, RR
- 9.18 (95% CI 2.05, 41.0)
- Extent of lung involvement, RR
- 3.28 (95% CI 1.12, 9.60)
Original publication
Lung function trajectory of rheumatoid arthritis–associated interstitial lung disease. Rheumatology (Oxford). Published 25 January 2023. doi:10.
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