Familial risk of seropositive rheumatoid arthritis and interaction with smoking: a population-based cohort study
Main finding · Seropositive RAResult — go to the resultHazard ratio 4.52 95% CI 3.98–5.12Authors' conclusion
Our findings indicate the possibility of an interaction between RA-associated genes and smoking.
Study context
- Population
- Individuals with first-degree relatives (FDRs), 2002–2018, National Health Insurance and Health Screening Program databases
- Participants
- 5,524,403 individuals
- Exposure
- Individuals with affected FDRs vs individuals with unaffected FDRs
- Outcome
- Seropositive RA (familial risk)
Methodological detailsNational Health Insurance and Health Screening Program databases, additive interaction (RERI)
- National Health Insurance and Health Screening Program databases
- Additive interaction (RERI)
Main finding
Seropositive RA
Hazard ratio
4.52
95% CI 3.98–5.12
Affected FDRvs Unaffected FDR
HR 4.52 (95% CI 3.98–5.12)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Smoking and risk of seropositive rheumatoid arthritis (RA), by intensity
| HR (95% CI) | ||
|---|---|---|
| Heavy smoking | 1.92 (1.70–2.18) | |
| Moderate smoking | 1.15 (1.04–1.28) | |
| 0.512Hazard ratio (log scale) |
Additive interaction between smoking and family history (RERI)
- Combined effect of smoking and family history higher than the sum of their individual effects, statistically non-significant: RERI
- 1.30 (95% CI −0.92, 3.51)
- Heavy smokers with a positive family history: RERI
- 4.13 (95% CI −0.88, 9.13)
- Moderate smokers with a positive family history: RERI
- 0.61 (95% CI −1.90, 3.13)
- Suggesting a dose-response interaction pattern
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Familial risk of seropositive rheumatoid arthritis and interaction with smoking: a population-based cohort study. Rheumatology (Oxford). Published 24 January 2023. doi:10.
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